• Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ, and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble polymer fibrin gives structural stability, strength, and adhesive surfaces for growing blood clots.
• Equally important, the exposure of its non-substrate thrombin-binding sites after fibrin clot formation promotes antithrombotic properties. Fibrinogen and fibrin have a major role in multiple biological processes in addition to hemostasis and thrombosis, i.e., fibrinolysis (during which the fibrin clot is broken down), matrix physiology (by interacting with factor XIII, plasminogen, vitronectin, and fibronectin), wound healing, inflammation, infection, cell interaction, angiogenesis, tumour growth, and metastasis. 

Strain specific FGG expression analysis in wild-type C57BL/6N mice and homozygous humanized B-hFGG mice by ELISA. Plasma was collected from male wild-type C57BL/6N mice (+/+) (n=3, 9-week-old) and homozygous B-hFGG mice (H/H) (n=3, 11-week-old). Expression level of mouse and human FGG were analyzed by ELISA (anti-mouse FGG ELISA kit: Abcam, ab108844; anti-human FGG ELISA kit: Abcam, ab108842). Mouse FGG was detectable in wild-type C57BL/6N mice. Human FGG was detectable in homozygous B-hFGG mice.