B-hIL12A/hIL12B mice
| Strain Name |
C57BL/6-Il12atm1(IL12A)Bcgen Il12btm1(IL12B)Bcgen/Bcgen
|
Common Name | B-hIL12A/hIL12B mice |
| Background | C57BL/6 | Catalog number |
120552 |
|
Related Genes |
IL12A: interleukin 12A, P35, IL12-A; IL12B: interleukin 12B, IL-12B | ||
|
NCBI Gene ID |
16159,16160 | ||
mRNA expression analysis
RT-PCR analysis of IL12A and IL12B gene.
The human IL12A but not mouse Il12a mRNA was detectable in splenocyte of the homozygous B-hIL12A/hIL12B mice.
The human IL12B but not mouse Il12b mRNA was detectable in thymus cell of the homozygous B-hIL12A/hIL12B mice.
Protein expression analysis
Strain specific IL12(heterodimer p70) expression analysis in homozygous B-hIL12A/hIL12B mice by ELISA. Serum was collected om WT (+/+) and homozygous B-hIL12A/IL12B mice (H/H) mice stimulated with anti-mCD3ε and anti-mCD28 in vivo (n=3), and analyzed by ELISA with species-specific IL12 ELISA kit. Mouse IL12 (p70) was detectable in WT mice. Human IL12 (p70) was exclusively detectable in homozygous B-hIL12A/IL12B mice (H/H) mice but not in WT mice. ND: Not detectable.
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