B-hPAI1 mice
| Strain Name |
C57BL/6N-Serpine1tm1(SERPINE1)Bcgen/Bcgen
|
Common Name | B-hPAI1 mice |
| Background | C57BL/6N | Catalog number | 111119 |
|
Related Genes |
SERPINE1 serpin family E member 1； PAI; PAI1; PAI-1; PLANH1 | ||
mRNA expression analysis
Strain specific analysis of m/hPAI1 gene expression in B-hPAI1 mice by RT-PCR.
Mouse Pai1 mRNA was detectable in the wild-type mice (+/+) and Human PAI1 mRNA was detectable only in B-hPAI1 mice .
Protein expression analysis
Strain specific PAI1 expression analysis in homozygous B-hPAI1 mice by ELISA.
Serum was collected from wild-type mice (+/+) and homozygous B-hPAI1 mice (H/H) sitimulated by LPS (2 μg/g body weight) for 8h, and analyzed by ELISA. Mouse PAI1 was detectable in wild-type mice and homozygous B-hPAI1 mice as the antibody is crossly reactive with PAI1 in human and mice. Human PAI1 was exclusively detectable in homozygous B-hPAI1 mice. ND: not detected.
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